“Let’s energize, rejuvenate, become nutritionally healthier, with the antioxidant, detoxifying, and immuno-protective health benefits of Glutathione, the most abundant antioxidant found in almost every body cell.”
-Nelson Gonzalez, MD and Augusto Agostini, PhD
-Nelson Gonzalez, MD and Augusto Agostini, PhD
To nutritionally complement our formidable Proteinic Duo, here’s a description of the OTHER VALUABLE SPECIAL NUTRIENTS contained in our unique BioActivPro TM formulation, which comprise our comprehensive, select group of Glutathione Precursors and MEEAPS components, aimed at optimizing its absorption & utilization at the cellular level:
*Setria® L-Glutathione (Reduced Form)
As previously described, Glutathione (GSH) empowers our body’s defense network against infections and diseases, as this, the most abundant endogenous antioxidant (as it resides in each of our body’s trillions of cells), is a critical regulator of oxidative stress and immune function.
While oral supplementation with GSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established, until clinical trials proved that to be the case with Setria® L-Glutathione (Reduced Form), which validated the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults, as a reduction in oxidative stress in the clinical trial individuals treated with Setria® clearly indicated decreases in the oxidized to reduced glutathione ratio in their whole blood after 6 months of supplementation.
Subjects in the clinical trial were 54 healthy adults (41 females/13 males), 28-72 years of age (mean=46.6 years). Let’s describe what the daily supplementation with 250 mg of Setria® (after 6 consecutive months) on these individuals showed :
a) Results of the study showed glutathione levels in the blood increased after one, three and six months vs. baseline. Glutathione levels increased 17 and 29 percent in blood and erythrocytes, respectively.
b) At six months, mean glutathione levels increased 30-35 percent in erythrocytes, plasma, and lymphocytes.
c) A reduction in oxidative stress was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months, and
d) According to the study, the effects of glutathione supplementation on the levels of the glutathione precursor cysteine in plasma and the activity of the rate-limiting glutathione biosynthetic enzyme GCL in erythrocytes were examined after the six-month study period.No changes were observed in cyst(e)ine concentrations or GCL activity.
This six-month clinical trial – led by Dr. John P. Richie of Penn State University – evaluated the efficacy of Setria® Glutathione supplementation at enhancing body stores of Glutathione, and the results show that glutathione supplementation may represent an effective intervention strategy to not only enhance body stores but also boost the body's immune function.
The cited results of the study (supported by Kyowa Hakko USA, Inc. and Kyowa Hakko Bio. Ltd., makers of Setria® L-Glutathione Reduced Form) -were published in the May 2014 issue of the European Journal of Nutrition.
Subjects in the clinical trial were 54 healthy adults (41 females/13 males), 28-72 years of age (mean=46.6 years). Let’s describe what the daily supplementation with 250 mg of Setria® (after 6 consecutive months) on these individuals showed :
a) Results of the study showed glutathione levels in the blood increased after one, three and six months vs. baseline. Glutathione levels increased 17 and 29 percent in blood and erythrocytes, respectively.
b) At six months, mean glutathione levels increased 30-35 percent in erythrocytes, plasma, and lymphocytes.
c) A reduction in oxidative stress was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months, and
d) According to the study, the effects of glutathione supplementation on the levels of the glutathione precursor cysteine in plasma and the activity of the rate-limiting glutathione biosynthetic enzyme GCL in erythrocytes were examined after the six-month study period.No changes were observed in cyst(e)ine concentrations or GCL activity.
This six-month clinical trial – led by Dr. John P. Richie of Penn State University – evaluated the efficacy of Setria® Glutathione supplementation at enhancing body stores of Glutathione, and the results show that glutathione supplementation may represent an effective intervention strategy to not only enhance body stores but also boost the body's immune function.
The cited results of the study (supported by Kyowa Hakko USA, Inc. and Kyowa Hakko Bio. Ltd., makers of Setria® L-Glutathione Reduced Form) -were published in the May 2014 issue of the European Journal of Nutrition.
*Turmeric (Curcuma longa) (Longvida® SD Optimized Curcumin)
This extraordinary Ayurvedic herb has found its way into the spotlight in the West because of its wide range of health benefits.
Turmeric is a potent antioxidant. Curcumin, its main active constituent, is as powerful an antioxidant as vitamins C, E and Beta-Carotene, making turmeric usage a consumer choice for liver disease protection, premature aging prevention, and brain health enhancement.
In addition, Turmeric induces Glutathione biosynthesis and is a powerful anti-inflammatory, easing conditions such as bursitis, arthritis and back pain. Turmeric’s anti-inflammatory action is likely due to a combination of three different properties. First, turmeric lowers the production of inflammation-inducing histamine. Secondly, it increases and prolongs the action of the body’s natural anti-inflammatory adrenal hormone, cortisol, and finally, turmeric improves circulation, thereby flushing toxins out of small joints where cellular wastes and inflammatory compounds are frequently trapped.
Research has also confirmed the digestive benefits of Turmeric. Turmeric acts as a cholagogue, stimulating bile production, thus, increasing the bodies’ ability to digest fats, improving digestion and eliminating toxins from the liver. Turmeric has also displayed anti-ulcer activity. By reducing the amount of acid secreted, it helps to protect the lining of the stomach where peptic ulcers occur.
Since one of the problems in curcumin absorption is that it gets broken down in the stomach quickly, we exclusively use Longvida® SD Optimized Curcumin in our formulation as it encapsulates curcumin to protect it from hydrolysis. This patented technology is called SLCP technology – Solid Lipid Curcumin Particle Technology. Through this technology, curcumin is protected from the acid in the stomach, so it gets dissolved in the point of absorption, which is the GI Tract. The end result is that higher levels of curcumin get to the target tissues.
Longvida® SD Optimized Curcumin aims to get as much free curcumin into the blood and tissues as possible. This formulation does not contain any turmeric oils, only curcumin. Experts have tested the effectiveness of Longvida compared to ordinary curcumin. In human studies, they found out that Longvida® SD Optimized Curcumin is 65 times more bioavailable based on maximum concentration in blood plasma, and is 100 times more bioavailable based on AUC or Area Under the Curve.
Longvida® SD was formulated by UCLA neuroscientists and Verdure Sciences. It focuses on curcumin’s ability to support neurogenesis, which is the regeneration of brain cells. Curcumin has been proven to increase the levels of BDNF (Brain-Derived Neurotrophic Factor) in the brain. BDNF is a type of hormone in the brain. As we grow older, the amount of BDNF in the brain drops, and this contributes to diseases like dementia and Alzheimer’s disease. Curcumin helps prevent these diseases by increasing the amount of BDNF in the brain.
Longvida® SD also takes advantage of curcumin’s antioxidant and anti-inflammatory properties to protect brain cells. Some brain diseases, such as Alzheimer’s disease, may be caused by amyloid-B protein fragments in the brain that cause Oxidative Stress and inflammation. Curcumin effectively binds with these fragments, which helps stop them from causing plaque between neurons, thus, helping prevent the onset of some brain diseases. In Longvida® SD’s formulation, the brain benefits a lot from curcumin’s antioxidant and anti-inflammatory properties.
Longvida® SD is the form (liposomal encapsulation) of Curcumin that works best for adverse health brain conditions . It is formulated to cross the blood-brain barrier, so it’s most effective for diseases like dementia, cognitive impairment, and Alzheimer’s disease.
Turmeric is a potent antioxidant. Curcumin, its main active constituent, is as powerful an antioxidant as vitamins C, E and Beta-Carotene, making turmeric usage a consumer choice for liver disease protection, premature aging prevention, and brain health enhancement.
In addition, Turmeric induces Glutathione biosynthesis and is a powerful anti-inflammatory, easing conditions such as bursitis, arthritis and back pain. Turmeric’s anti-inflammatory action is likely due to a combination of three different properties. First, turmeric lowers the production of inflammation-inducing histamine. Secondly, it increases and prolongs the action of the body’s natural anti-inflammatory adrenal hormone, cortisol, and finally, turmeric improves circulation, thereby flushing toxins out of small joints where cellular wastes and inflammatory compounds are frequently trapped.
Research has also confirmed the digestive benefits of Turmeric. Turmeric acts as a cholagogue, stimulating bile production, thus, increasing the bodies’ ability to digest fats, improving digestion and eliminating toxins from the liver. Turmeric has also displayed anti-ulcer activity. By reducing the amount of acid secreted, it helps to protect the lining of the stomach where peptic ulcers occur.
Since one of the problems in curcumin absorption is that it gets broken down in the stomach quickly, we exclusively use Longvida® SD Optimized Curcumin in our formulation as it encapsulates curcumin to protect it from hydrolysis. This patented technology is called SLCP technology – Solid Lipid Curcumin Particle Technology. Through this technology, curcumin is protected from the acid in the stomach, so it gets dissolved in the point of absorption, which is the GI Tract. The end result is that higher levels of curcumin get to the target tissues.
Longvida® SD Optimized Curcumin aims to get as much free curcumin into the blood and tissues as possible. This formulation does not contain any turmeric oils, only curcumin. Experts have tested the effectiveness of Longvida compared to ordinary curcumin. In human studies, they found out that Longvida® SD Optimized Curcumin is 65 times more bioavailable based on maximum concentration in blood plasma, and is 100 times more bioavailable based on AUC or Area Under the Curve.
Longvida® SD was formulated by UCLA neuroscientists and Verdure Sciences. It focuses on curcumin’s ability to support neurogenesis, which is the regeneration of brain cells. Curcumin has been proven to increase the levels of BDNF (Brain-Derived Neurotrophic Factor) in the brain. BDNF is a type of hormone in the brain. As we grow older, the amount of BDNF in the brain drops, and this contributes to diseases like dementia and Alzheimer’s disease. Curcumin helps prevent these diseases by increasing the amount of BDNF in the brain.
Longvida® SD also takes advantage of curcumin’s antioxidant and anti-inflammatory properties to protect brain cells. Some brain diseases, such as Alzheimer’s disease, may be caused by amyloid-B protein fragments in the brain that cause Oxidative Stress and inflammation. Curcumin effectively binds with these fragments, which helps stop them from causing plaque between neurons, thus, helping prevent the onset of some brain diseases. In Longvida® SD’s formulation, the brain benefits a lot from curcumin’s antioxidant and anti-inflammatory properties.
Longvida® SD is the form (liposomal encapsulation) of Curcumin that works best for adverse health brain conditions . It is formulated to cross the blood-brain barrier, so it’s most effective for diseases like dementia, cognitive impairment, and Alzheimer’s disease.
*Natural Astaxanthin (via AstaReal®)
According to the study Nishida et al., (2007) published on Carotenoid Science. Vol 11: 16-20, Natural Astaxanthin is the most powerful antioxidant known to science until this moment. That’s having a much stronger antioxidant power than vitamin C, Resveratrol, CoQ10, GreenTea catechins and vitamin E. Its power comes from its unique structure that allows it to quench free radicals in the inner and outer layer of the cell membrane unlike other antioxidants, thus making it stronger and more resilient.
As per its proven scientific results, we exclusively utilize AstaReal® Natural Astaxanthin (by Fuji CG) in our formulation.
It has a truly unique cultivation process that produces the purest and highest potency Natural Astaxanthin available. It is the most studied brand of Astaxanthin, and it is their product the one that has been used in the majority of human clinical studies, besides being the only producer offering a stable supply of Made in the USA natural astaxanthin, produced in Moses Lake, Washington.
Among the many important scientifically-validated health benefits of AstaReal®Natural Astaxanthin, we could mention its relevant proven contributions to the following four (4) health areas :
Muscle Endurance and Recovery, as it has demonstrated to improve muscle endurance through its ability to support muscle function and improve aerobic power, as well as in other studies, it has also been found to reduce lactic acid build-up and thus decrease fatigue.
Immune Health Function Balance , as it has also proven a strong ability to both balance and strengthen the foremost-important immune system function, therefore improving its ability to defend the body while also helping to suppress overactive immune responses. Additionally, it has shown to enhance antibody production and protecting immune cells against Oxidative Stress. Meanwhile, it has proven to be a solid supporter of a healthy gut, where approximately 70% of the immune system resides.
Eye and Vision Health, Clinical studies have also shown that Astaxanthin supplementation improves eye fatigue by quenching cellular inflammation that emerges during persistent visual stress and tension of the ciliary muscle, while also improving the symptoms linked to excessive computer and digital device use such as eye fatigue, eye irritation and blurred vision. In regards to enhancing Skin Health , it has scientifically-demonstrated a remarkable ability to optimize the health and radiance of the skin by providing protection and support to all layers, accomplishing this by revitalizing photo-aged skin via quenching oxidative stress in all skin layers. It has also proven to reduce the size of wrinkles and enhance skin micro-texture, while simultaneously improving elasticity in the skin by strengthening the collagen layer.
As per its proven scientific results, we exclusively utilize AstaReal® Natural Astaxanthin (by Fuji CG) in our formulation.
It has a truly unique cultivation process that produces the purest and highest potency Natural Astaxanthin available. It is the most studied brand of Astaxanthin, and it is their product the one that has been used in the majority of human clinical studies, besides being the only producer offering a stable supply of Made in the USA natural astaxanthin, produced in Moses Lake, Washington.
Among the many important scientifically-validated health benefits of AstaReal®Natural Astaxanthin, we could mention its relevant proven contributions to the following four (4) health areas :
Muscle Endurance and Recovery, as it has demonstrated to improve muscle endurance through its ability to support muscle function and improve aerobic power, as well as in other studies, it has also been found to reduce lactic acid build-up and thus decrease fatigue.
Immune Health Function Balance , as it has also proven a strong ability to both balance and strengthen the foremost-important immune system function, therefore improving its ability to defend the body while also helping to suppress overactive immune responses. Additionally, it has shown to enhance antibody production and protecting immune cells against Oxidative Stress. Meanwhile, it has proven to be a solid supporter of a healthy gut, where approximately 70% of the immune system resides.
Eye and Vision Health, Clinical studies have also shown that Astaxanthin supplementation improves eye fatigue by quenching cellular inflammation that emerges during persistent visual stress and tension of the ciliary muscle, while also improving the symptoms linked to excessive computer and digital device use such as eye fatigue, eye irritation and blurred vision. In regards to enhancing Skin Health , it has scientifically-demonstrated a remarkable ability to optimize the health and radiance of the skin by providing protection and support to all layers, accomplishing this by revitalizing photo-aged skin via quenching oxidative stress in all skin layers. It has also proven to reduce the size of wrinkles and enhance skin micro-texture, while simultaneously improving elasticity in the skin by strengthening the collagen layer.
* TMG (Trimethylglycine) Betaine Anhydrous
Let’s now get you acquainted with one of ‘best-kept-secret’ ingredients that have been scientifically proven to effectively promote Glutathione synthesis (primarily in the Liver) … TMG Betaine Anhydrous.
One of our first professional encounters with the important Betaine-Glutathione connection happened when reading information derived from biochemist and autism authority, Dr. Sandra Jill James’ lecture at the Autism One Conference in 2005, where she discussed how the metabolic pathway of trans-sulfuration appears to be disrupted in autistic children, resulting in autistic children being deficient in critical nutrients, including master antioxidant Glutathione.
Betaine is sold under its technical name of Trimethylglycine, or best known for its TMG acronym. It's made of the amino acid Glycine with three methyl groups attached to it. In the human body, TMG (Betaine) is naturally derived from the breakdown of Choline, and is found in a number of food sources, like spinach and quinoa, but primarily in Beets (Beta vulgaris), from where it gets its name. It should not be confused with Betaine HCL.
A recent study (from the University of Connecticut) indicated that daily supplementation with TMG (Betaine) may help increase exercise performance, muscle strength, power, as well as endurance in Athletes and Bodybuilders, and this may be due to TMG (Betaine)'s ability to increase levels of important anabolic substances while supporting a healthy balance of the catabolic hormone Cortisol.
Previous research also suggests that TMG (Betaine) supplementation increases nitric oxide and helps regulate cellular fluid volume, which could further promote muscle pump and overall muscle size. This is understandable, as this natural product is an osmolyte (has an affinity for water, and therefore, can increase the hydration and maintenance of hydration in cells), which makes it able to promote muscle growth.
In humans, most of TMG (Betaine)'s purported benefits derive from its role as a methyl donor. A methyl donor is any molecule that can transfer a methyl group, which is a carbon atom attached to three hydrogen atoms, to another molecule. Many important biochemical processes in the body rely on methylation, including thinking, detoxification, DNA integrity (cell repair and transfer), processing fats, energy production, and more.
The most critical reaction where TMG (Betaine) performs this function is in the methylation of the amino acid Homocysteine to form Methionine.
Methionine is a precursor for Cysteine, and Cysteine is a precursor for Glutathione, the master antioxidant, which resides in each of our body’s ten (10) trillion cells, protecting and detoxifying them from the damage of Free Radicals, which accumulation over time - if left uncontrolled - could lead to Oxidative Stress.
Additionally, Methionine is important in the body's internal synthesis of Creatine. So one way that TMG (Betaine) may boost muscle strength and size is by naturally increasing Creatine production in the body. Methionine also plays an important role in muscle protein synthesis, and specifically the process known as "translation." By having more Methionine available for this process, protein synthesis is ramped up, and therefore so is the potential for muscle growth and strength gains.
TMG (Betaine) also contributes the beneficial effect of supporting healthy Homocysteine levels. High Homocysteine levels have been shown to impair insulin signaling, which can interfere with muscle growth and fat loss.
Improved strength and power
A moderate amount of research suggests that giving resistance-trained subjects (Betaine) daily may increase the number of reps they can complete, which in turn contributes to increased strength. While the improvements in the studies were relatively minor, even minor improvements can be significant in trained athletes, who are looking for every edge they can get.
Some research also indicates that TMG (Betaine) can lead to improvements in peak and average power output. Other research suggests that taking TMG (Betaine) can significantly increase bench throw power, isometric bench press force, vertical jump power, and overall peak power.
Improved endurance
The research on TMG (Betaine) and endurance is still in its infancy. But supplementing with it has allowed some subjects to maintain high-speed sprints for longer periods.
Note, however, that TMG (Betaine) supplementation doesn’t seem to improve performance in long-distance endurance sports. So it probably won’t help you in a marathon.
Improved body composition
Long-term TMG (Betaine) supplementation may improve body composition as well. Subjects who takeTMG (Betaine) on a daily basis while on a structured training program may expect an enhancement of upper arm muscle mass, according to studies. Meanwhile, they may also gain overall lean body mass, and lose body fat, thus improving body composition.
Possible natural effects on cardiovascular health
TMG (Betaine) supplementation may consistently reduce Homocysteine levels. This is a good thing, because high levels of Homocysteine are linked to heart disease.
Word of Caution :
You should consider not taking a dose of 6 grams or more per day of TMG (Betaine), as some research has found that at this high daily dose, it may actually increase levels of LDL cholesterol and triglycerides in healthy subjects. But doses of 4 grams per day or less had shown no effect on blood lipids.
One of our first professional encounters with the important Betaine-Glutathione connection happened when reading information derived from biochemist and autism authority, Dr. Sandra Jill James’ lecture at the Autism One Conference in 2005, where she discussed how the metabolic pathway of trans-sulfuration appears to be disrupted in autistic children, resulting in autistic children being deficient in critical nutrients, including master antioxidant Glutathione.
Betaine is sold under its technical name of Trimethylglycine, or best known for its TMG acronym. It's made of the amino acid Glycine with three methyl groups attached to it. In the human body, TMG (Betaine) is naturally derived from the breakdown of Choline, and is found in a number of food sources, like spinach and quinoa, but primarily in Beets (Beta vulgaris), from where it gets its name. It should not be confused with Betaine HCL.
A recent study (from the University of Connecticut) indicated that daily supplementation with TMG (Betaine) may help increase exercise performance, muscle strength, power, as well as endurance in Athletes and Bodybuilders, and this may be due to TMG (Betaine)'s ability to increase levels of important anabolic substances while supporting a healthy balance of the catabolic hormone Cortisol.
Previous research also suggests that TMG (Betaine) supplementation increases nitric oxide and helps regulate cellular fluid volume, which could further promote muscle pump and overall muscle size. This is understandable, as this natural product is an osmolyte (has an affinity for water, and therefore, can increase the hydration and maintenance of hydration in cells), which makes it able to promote muscle growth.
In humans, most of TMG (Betaine)'s purported benefits derive from its role as a methyl donor. A methyl donor is any molecule that can transfer a methyl group, which is a carbon atom attached to three hydrogen atoms, to another molecule. Many important biochemical processes in the body rely on methylation, including thinking, detoxification, DNA integrity (cell repair and transfer), processing fats, energy production, and more.
The most critical reaction where TMG (Betaine) performs this function is in the methylation of the amino acid Homocysteine to form Methionine.
Methionine is a precursor for Cysteine, and Cysteine is a precursor for Glutathione, the master antioxidant, which resides in each of our body’s ten (10) trillion cells, protecting and detoxifying them from the damage of Free Radicals, which accumulation over time - if left uncontrolled - could lead to Oxidative Stress.
Additionally, Methionine is important in the body's internal synthesis of Creatine. So one way that TMG (Betaine) may boost muscle strength and size is by naturally increasing Creatine production in the body. Methionine also plays an important role in muscle protein synthesis, and specifically the process known as "translation." By having more Methionine available for this process, protein synthesis is ramped up, and therefore so is the potential for muscle growth and strength gains.
TMG (Betaine) also contributes the beneficial effect of supporting healthy Homocysteine levels. High Homocysteine levels have been shown to impair insulin signaling, which can interfere with muscle growth and fat loss.
Improved strength and power
A moderate amount of research suggests that giving resistance-trained subjects (Betaine) daily may increase the number of reps they can complete, which in turn contributes to increased strength. While the improvements in the studies were relatively minor, even minor improvements can be significant in trained athletes, who are looking for every edge they can get.
Some research also indicates that TMG (Betaine) can lead to improvements in peak and average power output. Other research suggests that taking TMG (Betaine) can significantly increase bench throw power, isometric bench press force, vertical jump power, and overall peak power.
Improved endurance
The research on TMG (Betaine) and endurance is still in its infancy. But supplementing with it has allowed some subjects to maintain high-speed sprints for longer periods.
Note, however, that TMG (Betaine) supplementation doesn’t seem to improve performance in long-distance endurance sports. So it probably won’t help you in a marathon.
Improved body composition
Long-term TMG (Betaine) supplementation may improve body composition as well. Subjects who takeTMG (Betaine) on a daily basis while on a structured training program may expect an enhancement of upper arm muscle mass, according to studies. Meanwhile, they may also gain overall lean body mass, and lose body fat, thus improving body composition.
Possible natural effects on cardiovascular health
TMG (Betaine) supplementation may consistently reduce Homocysteine levels. This is a good thing, because high levels of Homocysteine are linked to heart disease.
Word of Caution :
You should consider not taking a dose of 6 grams or more per day of TMG (Betaine), as some research has found that at this high daily dose, it may actually increase levels of LDL cholesterol and triglycerides in healthy subjects. But doses of 4 grams per day or less had shown no effect on blood lipids.
*Milk Thistle (Silybum marianum) (standardized to 80% Silymarin)
This is one of the most researched and scientifically-validated of all herbal remedies. Used for centuries by traditional folk medicine all across the world, Milk Thistle (Silybum marianum), is considered and respected as one of the most important phytonutrient gifts of Nature for efficiently supporting Liver function, and also has long been praised as a remedy to counteract immune system function imbalance (dysfunction).
Regarding the Liver, Milk Thistle may exert a protective and detoxifying action that safeguards it against the constant and destructive attacks of harmful oxidative substances called Free Radicals, principally produced by toxins from smoking, alcohol use or exposure to environmental contaminants, etc. Specifically, Silymarin, a unique flavonoid complex, which is the active component of the Milk Thistle plant, has been used for counteracting liver damage and biliary tract disease.
Furthermore, according to scientists, the secret to Milk Thistle’s healing prowess is its ability to enhance the intracellular production of the body’s most powerful antioxidant agent - Glutathione (GSH). Silymarin not only promotes the production of Glutathione (GSH) in body cells by preventing lipid peroxidation (oxidative damage of lipids), but also maintains Glutathione (GSH) levels. The Milk Thistle extract utilized in our formulation is standardized to contain 80% Silymarin.
Regarding the Liver, Milk Thistle may exert a protective and detoxifying action that safeguards it against the constant and destructive attacks of harmful oxidative substances called Free Radicals, principally produced by toxins from smoking, alcohol use or exposure to environmental contaminants, etc. Specifically, Silymarin, a unique flavonoid complex, which is the active component of the Milk Thistle plant, has been used for counteracting liver damage and biliary tract disease.
Furthermore, according to scientists, the secret to Milk Thistle’s healing prowess is its ability to enhance the intracellular production of the body’s most powerful antioxidant agent - Glutathione (GSH). Silymarin not only promotes the production of Glutathione (GSH) in body cells by preventing lipid peroxidation (oxidative damage of lipids), but also maintains Glutathione (GSH) levels. The Milk Thistle extract utilized in our formulation is standardized to contain 80% Silymarin.
*N-Acetyl-Cysteine (NAC)
N-Acetyl Cysteine (NAC) produces numerous beneficial effects in many human tissues both by supporting natural antioxidant systems and by favorably affecting expression of genes involved in the inflammatory response.
Recognized as one of the best endogenous Glutathione production-precursors in the body, and shown to support lung and bronchial health, NAC studies have reported improvements in exercise capacity (Kelly MK, et al. Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. Respir Physiol Neurobiol. 2009 Jan 1; 165(1): 67-72.), and reduced muscle soreness associated with exercise (Silva LA, et al. N-acetylcysteine supplementation and oxidative damage and inflammatory response after eccentric exercise. Int J Sport Nutr Exerc Metab. 2008 Aug; 18(4): 379-388.), thus increasing power and reducing fatigue in healthy, recreationally-active adults.
NAC also protects our liver and kidneys from toxins and pollutants including heavy metals, achieving these actions, in part, promoting healthy Glutathione production levels within all body cells by facilitating the removal of these toxins and pollutants from tissues and protecting them (tissues) from their free radical damage, while also supporting and protecting (as we mentioned before) upper respiratory tract and immune system health, as well as delaying muscle fatigue and accelerating muscle growth.
The latter (delaying muscle fatigue and accelerating muscle growth) is one reason why it's quite popular with bodybuilders and professional athletes seeking to gain lean muscle size (volume), as NAC has also been shown to slow and sometimes prevent the muscle loss that normally occurs as part of the aging process.
Recently, researchers have shown that Oxidative Stress in the brain may play a critical role in the Parkinson's disease process, and that this stress also lowers levels of Glutathione. Studies in brain cells have shown that NAC helps reduce oxidative damage to neurons by helping restore the levels of the antioxidant Glutathione.
Recognized as one of the best endogenous Glutathione production-precursors in the body, and shown to support lung and bronchial health, NAC studies have reported improvements in exercise capacity (Kelly MK, et al. Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. Respir Physiol Neurobiol. 2009 Jan 1; 165(1): 67-72.), and reduced muscle soreness associated with exercise (Silva LA, et al. N-acetylcysteine supplementation and oxidative damage and inflammatory response after eccentric exercise. Int J Sport Nutr Exerc Metab. 2008 Aug; 18(4): 379-388.), thus increasing power and reducing fatigue in healthy, recreationally-active adults.
NAC also protects our liver and kidneys from toxins and pollutants including heavy metals, achieving these actions, in part, promoting healthy Glutathione production levels within all body cells by facilitating the removal of these toxins and pollutants from tissues and protecting them (tissues) from their free radical damage, while also supporting and protecting (as we mentioned before) upper respiratory tract and immune system health, as well as delaying muscle fatigue and accelerating muscle growth.
The latter (delaying muscle fatigue and accelerating muscle growth) is one reason why it's quite popular with bodybuilders and professional athletes seeking to gain lean muscle size (volume), as NAC has also been shown to slow and sometimes prevent the muscle loss that normally occurs as part of the aging process.
Recently, researchers have shown that Oxidative Stress in the brain may play a critical role in the Parkinson's disease process, and that this stress also lowers levels of Glutathione. Studies in brain cells have shown that NAC helps reduce oxidative damage to neurons by helping restore the levels of the antioxidant Glutathione.
*Montmorency Tart Cherry Powder
Montmorency tart cherries (Prunus cerasus) are now more commonly lauded for their health benefits than their culinary prowess, as extensive research has put tart cherries at the top of the superfruit totem pole .
Numerous universities and research institutions have conducted studies regarding this cherry variety in the areas of muscle recovery, gout, inflammation and sleep (via naturally occurring Melatonin). They may naturally help the body increase its level of Melatonin, an important hormone that naturally occurs in the brain (it is made in the pineal gland), which besides been directly linked to improved sleep, is also a major precursor of Glutathione at the cellular level.
Additionally, Melatonin functions as an antioxidant, and Montmorency tart cherry is one of its principal natural food sources.
In terms of its promising health benefits for athletes and sports recovery to help relieve muscle and joint soreness, results from one of the Tart Cherry studies conducted at a Texas university (on acute Endurance exercise performance in aerobically trained individuals) revealed that short-term supplementation of Montmorency powdered tart cherries surrounding an endurance challenge attenuated markers of muscle catabolism, reduced immune and inflammatory stress, better maintained redox balance, and increased performance in aerobically trained
individuals. Meanwhile, another study at that same university (on an acute bout of intense lower body strength exercise in Resistance trained males) concluded that short-term supplementation of Montmorency powdered tart cherries appears to be an effective dietary supplement to attenuate muscle soreness, strength decrement during recovery, and markers of muscle catabolism in resistance-trained individuals.
Published scientific studies also show that Montmorency tart cherries abundantly contain unique Anthocyanins - one of Nature’s most potent classes of flavonoids - and other compounds that naturally may help mediate the inflammatory process, including nutritionally-supporting the body to reduce inflammation and ease the pain of osteoarthritis and gout, one of the most painful arthritic manifestations. Anthocyanins are powerful nutrients responsible for the deep colors in some berries, fruits, and vegetables, and anthocyanin-rich foods, such as tart cherries deliver substantial antioxidant and anti-inflammatory act.
Tart cherries contain 19 times more beta-carotene than blueberries, and strawberries. In addition, they are a source of vitamin C, potassium, magnesium, iron and folate, as well as of other phenolic compounds, such as gallic acid, p-coumaric acid, kaempferol, and quercetin, all of which are potent antioxidants.
Regarding Montmorency Tart Cherry’s health-benefiting, nutritionally-supporting impact that may help patients suffering Gout, one of the most painful arthritic conditions, we’ll like to share information that in a 2003 study, 280 grams of cherries (about 45 cherries) was given to 10 healthy women. Blood uric acid levels decreased by 14% after 5 hours and excretion of uric acid increased. CRP levels also decreased slightly (Jacob RA, et al. J Nutr 2003;133:1826–9).
Also in a 2011 randomized, placebo-controlled crossover study, 10 participants consumed 8 oz/day of either 100% tart cherry juice or placebo beverage for 4 weeks, with a 2-week washout period between switching treatments. Although participants had normal uric acid levels, 7/10 participants displayed reduced serum uric acid levels after tart cherry juice consumption. The erythrocyte sedimentation rate (ESR), an indicator of inflammation, was significantly lower with tart cherry juice treatment versus placebo (Martin KR, et al. FASEB 2011;25;339.2).
Research studies from the University of Michigan have also demonstrated that Tart Cherry consumption has been linked to a number of important cardiovascular benefits — from overall anti-inflammation to reductions in bad cholesterol levels, to decreased risk for atherosclerosis and for the Metabolic Syndrome — all important heart disease risk factors.
And last but not least, researchers continue to uncover new and novel benefits of tart cherries. Some preliminary research has linked tart cherry juice to improvements in sleep and sleep patterns. In one pilot study, a team of University of Pennsylvania, University of Rochester and VA Center of Canandaigua researchers found that drinking tart cherry juice daily helped reduce the severity of insomnia and time spent awake after going to sleep. The 15 older adults saved about 17 minutes of wake time after going to sleep, on average, when drinking cherry juice daily, compared to when they were drinking the juice drink. A second study found that healthy adults experienced improved sleep time and a 5-6 percent increase in overall sleep efficiency after drinking two servings of tart cherry juice for a week, compared to drinking a fruit cocktail. The volunteers also reported less daytime napping time while drinking the tart cherry juice.
Numerous universities and research institutions have conducted studies regarding this cherry variety in the areas of muscle recovery, gout, inflammation and sleep (via naturally occurring Melatonin). They may naturally help the body increase its level of Melatonin, an important hormone that naturally occurs in the brain (it is made in the pineal gland), which besides been directly linked to improved sleep, is also a major precursor of Glutathione at the cellular level.
Additionally, Melatonin functions as an antioxidant, and Montmorency tart cherry is one of its principal natural food sources.
In terms of its promising health benefits for athletes and sports recovery to help relieve muscle and joint soreness, results from one of the Tart Cherry studies conducted at a Texas university (on acute Endurance exercise performance in aerobically trained individuals) revealed that short-term supplementation of Montmorency powdered tart cherries surrounding an endurance challenge attenuated markers of muscle catabolism, reduced immune and inflammatory stress, better maintained redox balance, and increased performance in aerobically trained
individuals. Meanwhile, another study at that same university (on an acute bout of intense lower body strength exercise in Resistance trained males) concluded that short-term supplementation of Montmorency powdered tart cherries appears to be an effective dietary supplement to attenuate muscle soreness, strength decrement during recovery, and markers of muscle catabolism in resistance-trained individuals.
Published scientific studies also show that Montmorency tart cherries abundantly contain unique Anthocyanins - one of Nature’s most potent classes of flavonoids - and other compounds that naturally may help mediate the inflammatory process, including nutritionally-supporting the body to reduce inflammation and ease the pain of osteoarthritis and gout, one of the most painful arthritic manifestations. Anthocyanins are powerful nutrients responsible for the deep colors in some berries, fruits, and vegetables, and anthocyanin-rich foods, such as tart cherries deliver substantial antioxidant and anti-inflammatory act.
Tart cherries contain 19 times more beta-carotene than blueberries, and strawberries. In addition, they are a source of vitamin C, potassium, magnesium, iron and folate, as well as of other phenolic compounds, such as gallic acid, p-coumaric acid, kaempferol, and quercetin, all of which are potent antioxidants.
Regarding Montmorency Tart Cherry’s health-benefiting, nutritionally-supporting impact that may help patients suffering Gout, one of the most painful arthritic conditions, we’ll like to share information that in a 2003 study, 280 grams of cherries (about 45 cherries) was given to 10 healthy women. Blood uric acid levels decreased by 14% after 5 hours and excretion of uric acid increased. CRP levels also decreased slightly (Jacob RA, et al. J Nutr 2003;133:1826–9).
Also in a 2011 randomized, placebo-controlled crossover study, 10 participants consumed 8 oz/day of either 100% tart cherry juice or placebo beverage for 4 weeks, with a 2-week washout period between switching treatments. Although participants had normal uric acid levels, 7/10 participants displayed reduced serum uric acid levels after tart cherry juice consumption. The erythrocyte sedimentation rate (ESR), an indicator of inflammation, was significantly lower with tart cherry juice treatment versus placebo (Martin KR, et al. FASEB 2011;25;339.2).
Research studies from the University of Michigan have also demonstrated that Tart Cherry consumption has been linked to a number of important cardiovascular benefits — from overall anti-inflammation to reductions in bad cholesterol levels, to decreased risk for atherosclerosis and for the Metabolic Syndrome — all important heart disease risk factors.
And last but not least, researchers continue to uncover new and novel benefits of tart cherries. Some preliminary research has linked tart cherry juice to improvements in sleep and sleep patterns. In one pilot study, a team of University of Pennsylvania, University of Rochester and VA Center of Canandaigua researchers found that drinking tart cherry juice daily helped reduce the severity of insomnia and time spent awake after going to sleep. The 15 older adults saved about 17 minutes of wake time after going to sleep, on average, when drinking cherry juice daily, compared to when they were drinking the juice drink. A second study found that healthy adults experienced improved sleep time and a 5-6 percent increase in overall sleep efficiency after drinking two servings of tart cherry juice for a week, compared to drinking a fruit cocktail. The volunteers also reported less daytime napping time while drinking the tart cherry juice.
*Acetyl L-Carnitine (ALCAR) Powder
Acetyl-L-Carnitine Powder (sometimes shortened to ALCAR) is a type of L-Carnitine that has been acetylized. It is naturally produced in the body and is derived from the two essential amino acids, Methionine and Lysine. Due to the association that ALCAR has with the specific acetyl group that it belongs to, it is known for the great variety of benefits it provides related to overall mental health. It is also an antioxidant.
Profound effects to mitochondrial function make this compound useful to enhance overall quality of life, as it has demonstrated anti-aging qualities, thus especially helping Seniors. There’s significant amount of studies where positive improvements in human cognitive functions was seen, although they are focused on elderly and not much on healthy young people. Nevertherless, it has also been scientifically shown to act as a ‘nootropic’ (thus increasing IQ and performance) for all adults - young and old alike.
It is popularly known as ‘a good energy booster’ for gym and aerobic exercise, as well as a ‘fatigue reducer’, and as a general enhancer of well-being.
Profound effects to mitochondrial function make this compound useful to enhance overall quality of life, as it has demonstrated anti-aging qualities, thus especially helping Seniors. There’s significant amount of studies where positive improvements in human cognitive functions was seen, although they are focused on elderly and not much on healthy young people. Nevertherless, it has also been scientifically shown to act as a ‘nootropic’ (thus increasing IQ and performance) for all adults - young and old alike.
It is popularly known as ‘a good energy booster’ for gym and aerobic exercise, as well as a ‘fatigue reducer’, and as a general enhancer of well-being.
*Beta-Alanine (B-A)
Beta-Alanine (B-A) is a natural amino acid, the reason it is called beta is the beta isomer of the non-essential amino acid alanine. Unlike traditional amino acids, Beta-Alanine is not used for the synthesis of proteins, its main function appears to be the synthesis of Carnosine, which is a di-peptide found in high concentrations in skeletal muscle.
Carnosine has a number of important physiological activities in muscle tissue. It serves as a primary PH buffer, increases cellular sensitivity to Calcium, which is a trigger in muscle contractions, and acts as an antioxidant. Carnosine continues to have physiological benefits through the protection of muscle proteins from oxidation and glycation (reaction of sugars with proteins).
Aging is associated with a significant reduction in skeletal muscle. Carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing with Beta-Alanine has been shown to significantly increase skeletal muscle Carnosine, as mentioned previously. Through Beta-Alanine supplementation, scientific research has proven that our aging populations can improve intracellular pH control, and improve muscle endurance. The researchers also believe that Beta-Alanine supplementation could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.
On the other hand, Beta-Alanine is a nutritional supplement widely used by Athletes and Bodybuilders to improve performance. It alone, however, cannot be turned into a protein. As mentioned before, its role is to promote high intramuscular concentrations of Carnosine, a small molecule composed of the amino acids Histidine and Alanine. Carnosine acts as a buffering agent (against the hydronium ions and lactic acid which forms during exercise), and thus helps maintain an optimal muscle pH range which delays the onset of muscular failure.
It increases Muscle Mass, as research shows that supplementing with Beta-Alanine improves Carnosine concentrations in muscles which will affect your strength, lean body mass, power and endurance gains. The study concluded that concurrent high-intensity interval training (HIIT) along with beta alanine supplementation results in significant increases in lean body mass compared to HIIT alone. Research has also proven that Beta-Alanine boosts muscular anaerobic endurance, as it increases the potential to improve physical performance during high-intensity exercise. The researchers also found that some aspects of endurance performance, such as anaerobic threshold and time to exhaustion, can also be enhanced.
Additionally, it has been scientifically validated that it increases exercise capacity so Athletes and Bodybuilders can train harder and longer. According to a study published in the December 2009 issue of “Amino Acids,” the supplementing with Beta-Alanine increases muscle Carnosine concentrations which can ultimately increase your ability to perform high-intensity exercise. Likewise, results of a study in the December 2008 issue of the “International Journal of Sports Medicine” showed that four weeks of Beta-Alanine supplementation can significantly improve muscular endurance during resistance training.
It also increases Aerobic Endurance. Researchers writing in the April 2009 issue of “Medicine and Science in Sports and Exercise” investigated the effect of beta alanine on cyclists, measuring sprint performance at the end of an endurance cycling race. They found that compared to a placebo, Beta -Alanine supplementation significantly enhanced sprint performance.
Carnosine has a number of important physiological activities in muscle tissue. It serves as a primary PH buffer, increases cellular sensitivity to Calcium, which is a trigger in muscle contractions, and acts as an antioxidant. Carnosine continues to have physiological benefits through the protection of muscle proteins from oxidation and glycation (reaction of sugars with proteins).
Aging is associated with a significant reduction in skeletal muscle. Carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing with Beta-Alanine has been shown to significantly increase skeletal muscle Carnosine, as mentioned previously. Through Beta-Alanine supplementation, scientific research has proven that our aging populations can improve intracellular pH control, and improve muscle endurance. The researchers also believe that Beta-Alanine supplementation could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.
On the other hand, Beta-Alanine is a nutritional supplement widely used by Athletes and Bodybuilders to improve performance. It alone, however, cannot be turned into a protein. As mentioned before, its role is to promote high intramuscular concentrations of Carnosine, a small molecule composed of the amino acids Histidine and Alanine. Carnosine acts as a buffering agent (against the hydronium ions and lactic acid which forms during exercise), and thus helps maintain an optimal muscle pH range which delays the onset of muscular failure.
It increases Muscle Mass, as research shows that supplementing with Beta-Alanine improves Carnosine concentrations in muscles which will affect your strength, lean body mass, power and endurance gains. The study concluded that concurrent high-intensity interval training (HIIT) along with beta alanine supplementation results in significant increases in lean body mass compared to HIIT alone. Research has also proven that Beta-Alanine boosts muscular anaerobic endurance, as it increases the potential to improve physical performance during high-intensity exercise. The researchers also found that some aspects of endurance performance, such as anaerobic threshold and time to exhaustion, can also be enhanced.
Additionally, it has been scientifically validated that it increases exercise capacity so Athletes and Bodybuilders can train harder and longer. According to a study published in the December 2009 issue of “Amino Acids,” the supplementing with Beta-Alanine increases muscle Carnosine concentrations which can ultimately increase your ability to perform high-intensity exercise. Likewise, results of a study in the December 2008 issue of the “International Journal of Sports Medicine” showed that four weeks of Beta-Alanine supplementation can significantly improve muscular endurance during resistance training.
It also increases Aerobic Endurance. Researchers writing in the April 2009 issue of “Medicine and Science in Sports and Exercise” investigated the effect of beta alanine on cyclists, measuring sprint performance at the end of an endurance cycling race. They found that compared to a placebo, Beta -Alanine supplementation significantly enhanced sprint performance.
*Magnesium Malate
We utilize Magnesium Malate in our formulation. It is a combination of Magnesium fortified with Malic Acid, which may be beneficial for pain relief, fatigue, constipation, or a variety of other muscular, metabolic, and physical imbalances.
This powder (also known as magnesium salt with malic acid) is also noted for soothing muscles and speeding recovery time after extended workouts or training.
Studies have shown that only about 25% of U.S. adults are at or above the recommended daily amount of 310 to 320 milligrams for women and 400 to 420 milligrams for men. In fact, more than a decade ago, the 2005-2006 National Health and Nutrition Examination Survey (NHANES) revealed that at least half (50%) of the U.S. population had inadequate intakes of Magnesium.
But no matter what the real percentage may presently be, it’s a fact that a large portion of the population could be facing a Magnesium deficiency.
Magnesium is an essential mineral that is required by virtually every cell, and it’s an essential co-factor in more than 300 biochemical (enzymatic) reactions in the body that sustain and regulate basic human health and function - including the liver enzyme responsible for converting vitamin D to its active form. Some of these hundreds of processes include : muscle contraction and relaxation, nerve function, cardiac activity, blood pressure regulation, hormonal interactions, immunity, bone health and the metabolism of proteins, fats and nucleic acids, among many others.
Its excellent healthy effects may be based on how it facilitates the body's use of oxygen. Magnesium is to plant chlorophyll as iron is to human hemoglobin. In our body, magnesium-rich chlorophyll supplies the means to drive our mitochondrial pump, creating life-giving energy. This means magnesium provides oxygen to our muscles, making it a most important nutrient for athletes and non-athletes alike.
Glutathione, the body’s premier antioxidant, could not be produced without Magnesium, as this mineral plays a vital role in its synthesis via the proper functioning of the enzyme Gamma Glutamyl Transpeptidase (GGT), which is the only enzyme located on the outside of plasma cell membranes, where it breaks down circulating extracellular Glutathione and releases the all-important amino acid Cysteine for the intracellular re-assembling of Glutathione.
This means that GGT is involved in Cysteine delivery to tissues demanding it at the moment in response to Oxidative Stress or a pathogen. (Gamma-glutamyl transpeptidase in Glutathione biosynthesis. Zhang H et al. Methods Enzymol. 2005;401:468-83.)
Magnesium also stimulates the hormone Calcitonin, which helps support healthy bone structure by drawing calcium out of the blood and tissues and back into the bones.
It also plays a key role in the production of Adenosine TriPhosphate (ATP)… the body’s master energy molecule, as this mineral is crucial for cellular respiration (or energy metabolism) by the activation of enzymes known as ATPases, which are needed to generate it.
When ATP is broken down, energy is released for all muscle contractions, and when exercising strenuously, this turnover is extremely high, meaning that ATP needs to be synthesized quickly. Thus a shortfall of Magnesium can limit energy production, leading to fatigue, lethargy, reduced power, muscle twitches or cramps.
Magnesium plays a structural role in bones, cell membranes, and chromosomes. It’s required for the active transport of other metal ions across cell membranes, thus affecting nerve transmission, muscle contraction, and heart rhythm. And it’s also required for many cell-signaling functions (the conveyance of chemical messages within and between cells).
Malic acid, on the other hand, is a substance found in our body, which is a key component (along with magnesium, oxygen, & B-vitamins) to create energy, as it helps create the all-important ATP molecule of cellular energy even under low oxygen conditions. As a supplement, Malic acid is found in fruits, especially apples (as a matter of fact, in Latin, “malium” means apple).
This powder (also known as magnesium salt with malic acid) is also noted for soothing muscles and speeding recovery time after extended workouts or training.
Studies have shown that only about 25% of U.S. adults are at or above the recommended daily amount of 310 to 320 milligrams for women and 400 to 420 milligrams for men. In fact, more than a decade ago, the 2005-2006 National Health and Nutrition Examination Survey (NHANES) revealed that at least half (50%) of the U.S. population had inadequate intakes of Magnesium.
But no matter what the real percentage may presently be, it’s a fact that a large portion of the population could be facing a Magnesium deficiency.
Magnesium is an essential mineral that is required by virtually every cell, and it’s an essential co-factor in more than 300 biochemical (enzymatic) reactions in the body that sustain and regulate basic human health and function - including the liver enzyme responsible for converting vitamin D to its active form. Some of these hundreds of processes include : muscle contraction and relaxation, nerve function, cardiac activity, blood pressure regulation, hormonal interactions, immunity, bone health and the metabolism of proteins, fats and nucleic acids, among many others.
Its excellent healthy effects may be based on how it facilitates the body's use of oxygen. Magnesium is to plant chlorophyll as iron is to human hemoglobin. In our body, magnesium-rich chlorophyll supplies the means to drive our mitochondrial pump, creating life-giving energy. This means magnesium provides oxygen to our muscles, making it a most important nutrient for athletes and non-athletes alike.
Glutathione, the body’s premier antioxidant, could not be produced without Magnesium, as this mineral plays a vital role in its synthesis via the proper functioning of the enzyme Gamma Glutamyl Transpeptidase (GGT), which is the only enzyme located on the outside of plasma cell membranes, where it breaks down circulating extracellular Glutathione and releases the all-important amino acid Cysteine for the intracellular re-assembling of Glutathione.
This means that GGT is involved in Cysteine delivery to tissues demanding it at the moment in response to Oxidative Stress or a pathogen. (Gamma-glutamyl transpeptidase in Glutathione biosynthesis. Zhang H et al. Methods Enzymol. 2005;401:468-83.)
Magnesium also stimulates the hormone Calcitonin, which helps support healthy bone structure by drawing calcium out of the blood and tissues and back into the bones.
It also plays a key role in the production of Adenosine TriPhosphate (ATP)… the body’s master energy molecule, as this mineral is crucial for cellular respiration (or energy metabolism) by the activation of enzymes known as ATPases, which are needed to generate it.
When ATP is broken down, energy is released for all muscle contractions, and when exercising strenuously, this turnover is extremely high, meaning that ATP needs to be synthesized quickly. Thus a shortfall of Magnesium can limit energy production, leading to fatigue, lethargy, reduced power, muscle twitches or cramps.
Magnesium plays a structural role in bones, cell membranes, and chromosomes. It’s required for the active transport of other metal ions across cell membranes, thus affecting nerve transmission, muscle contraction, and heart rhythm. And it’s also required for many cell-signaling functions (the conveyance of chemical messages within and between cells).
Malic acid, on the other hand, is a substance found in our body, which is a key component (along with magnesium, oxygen, & B-vitamins) to create energy, as it helps create the all-important ATP molecule of cellular energy even under low oxygen conditions. As a supplement, Malic acid is found in fruits, especially apples (as a matter of fact, in Latin, “malium” means apple).
For Athletes
Magnesium plays a pivotal role in energy production, thus making it a must for athletic performance. Athletes in particular might find it easy to explain away fatigue or muscle cramps, lowered immunity, and even altered heart rates, and indeed these symptoms are common and multi-faceted in cause. However, a simple Magnesium deficiency could also be the underlying factor.
There is emerging evidence that Magnesium requirements are significantly elevated in Athletes, and that performance might benefit from higher intakes. Aside from being used up in the production of energy, magnesium might also assist performance by reducing accumulation of lactic acid and reducing the perception of fatigue during strenuous exercise through its action on the nervous system. Overworked muscles produce free radicals, and magnesium aids in the production of Glutathione, that besides been the body’s master antioxidant and detoxifier, also enhances performance, prevents lactic acid build-up, and shortens recovery time.
In Athletes, Magnesium deficiency is often found in the Overtraining Syndrome (its various signs and symptoms), which can result in hormonal, nutritional, mental/emotional, muscular, neurological and other imbalances. These, in turn, can cause fatigue, depression, injuries and poor performance to name a few problems. If muscles are deficient in magnesium, they become irritated and on edge developing tics, twitches, and outright spasms or "charley horses" as they are known when they occur in our calves. If you are feeling generally irritated and on edge, magnesium deficiency may be the cause.
If not counteract with dynamic nutritional support to enhance Glutathione antioxidant production at the cellular level, this situation may well contribute to the development of Oxidative Stress (with its dreadful consequences) in the individual.
Magnesium is also lost through sweat, so athletes training hard in hot and humid environments might further increase demands. Research suggests that endurance athletes can safely consume 500 to 800 mg daily, and there is debate as to whether this amount should be higher still.
For Seniors
Inadequate Magnesium intake is especially common in older persons, and Sarcopenia (loss of muscle mass due to aging) as well as Dynapenia (loss of muscle strength) are prevalent conditions in older persons, and are strong, independent risk factors for frailty, disability and mortality.
Accordingly, as Magnesium nutritionally supports metabolism, energy production (ATP), and optimal cellular function, elderly persons that suffer these adverse health conditions - by supplementing with it on a daily basis - may notice greater physical and mental energy, reduced fatigue, and often a greater sense of overall well-being.
A research study published (July 2014) in the American Journal of Clinical Nutrition corroborated that Magnesium supplementation can improve physical performance in older women. It tested the effect of Magnesium on older women’s ability to carry out everyday functional movements such as lifting and carrying, alongside other measures of strength and balance. These findings suggest a role for Magnesium supplementation in preventing or delaying the age-related decline in physical performance, particularly in magnesium-deficient individuals.
There is emerging evidence that Magnesium requirements are significantly elevated in Athletes, and that performance might benefit from higher intakes. Aside from being used up in the production of energy, magnesium might also assist performance by reducing accumulation of lactic acid and reducing the perception of fatigue during strenuous exercise through its action on the nervous system. Overworked muscles produce free radicals, and magnesium aids in the production of Glutathione, that besides been the body’s master antioxidant and detoxifier, also enhances performance, prevents lactic acid build-up, and shortens recovery time.
In Athletes, Magnesium deficiency is often found in the Overtraining Syndrome (its various signs and symptoms), which can result in hormonal, nutritional, mental/emotional, muscular, neurological and other imbalances. These, in turn, can cause fatigue, depression, injuries and poor performance to name a few problems. If muscles are deficient in magnesium, they become irritated and on edge developing tics, twitches, and outright spasms or "charley horses" as they are known when they occur in our calves. If you are feeling generally irritated and on edge, magnesium deficiency may be the cause.
If not counteract with dynamic nutritional support to enhance Glutathione antioxidant production at the cellular level, this situation may well contribute to the development of Oxidative Stress (with its dreadful consequences) in the individual.
Magnesium is also lost through sweat, so athletes training hard in hot and humid environments might further increase demands. Research suggests that endurance athletes can safely consume 500 to 800 mg daily, and there is debate as to whether this amount should be higher still.
For Seniors
Inadequate Magnesium intake is especially common in older persons, and Sarcopenia (loss of muscle mass due to aging) as well as Dynapenia (loss of muscle strength) are prevalent conditions in older persons, and are strong, independent risk factors for frailty, disability and mortality.
Accordingly, as Magnesium nutritionally supports metabolism, energy production (ATP), and optimal cellular function, elderly persons that suffer these adverse health conditions - by supplementing with it on a daily basis - may notice greater physical and mental energy, reduced fatigue, and often a greater sense of overall well-being.
A research study published (July 2014) in the American Journal of Clinical Nutrition corroborated that Magnesium supplementation can improve physical performance in older women. It tested the effect of Magnesium on older women’s ability to carry out everyday functional movements such as lifting and carrying, alongside other measures of strength and balance. These findings suggest a role for Magnesium supplementation in preventing or delaying the age-related decline in physical performance, particularly in magnesium-deficient individuals.
*MSM (Methylsulfonylmethane)
Methylsulfonylmethane (MSM) is an organic sulfur-containing nutrient that provides nutritionally essential sulfur and methyl groups, and whichwhich play an important role in the synthesis of master antioxidant Glutathione (GSH). This natural ingredient has been recently confirmed by Ohio State University researchers as an enhancer of the intracellular production of tri-peptide Gluthathione in the Liver.
Sulfur is a critically active component in the reduced (active) form of a Glutathione molecule (GSH). Sulfur is represented by “SH” (Sulfhydryl group) in the common abbreviation for Glutathione (GSH). It is the sulfur-containing amino acid Cysteine, the most crucial building block for Glutathione, that contributes Sulfur to it. At low levels of intake, Cysteine is preferentially incorporated into proteins rather than Glutathione. Thus, the availability of Cysteine determines how much Glutathione and how fast a cell can produce in response to an attack threat by “our body’s enemies”, such as free radicals, toxins and/or heavy metals, etc. To face, counteract and defeat such “enemy” attacks, Glutathione’s antioxidant and detoxifying powers are performed by Sulfur, which “sticks” to the attacking enemy substance and eliminates it from the body.
Additionally, MSM supplementation may help maintain Glutathione levels by helping decrease inflammation and Oxidative Stress, as well as by participating in the metabolism of Cysteine and Methionine, and by contributing the continuous supply of Sulfur for many vital processes in the body. Other research studies reveal of MSM’s mild protective effect on articular (bone) cartilage when facing osteoarthritis and RA, which seems to be primarily temporary pain relief. Nevertheless, published peer-reviewed clinical research in the U.S. has shown MSM is safe and effective in increasing joint comfort and supporting a normal range of motion.
Sulfur is a critically active component in the reduced (active) form of a Glutathione molecule (GSH). Sulfur is represented by “SH” (Sulfhydryl group) in the common abbreviation for Glutathione (GSH). It is the sulfur-containing amino acid Cysteine, the most crucial building block for Glutathione, that contributes Sulfur to it. At low levels of intake, Cysteine is preferentially incorporated into proteins rather than Glutathione. Thus, the availability of Cysteine determines how much Glutathione and how fast a cell can produce in response to an attack threat by “our body’s enemies”, such as free radicals, toxins and/or heavy metals, etc. To face, counteract and defeat such “enemy” attacks, Glutathione’s antioxidant and detoxifying powers are performed by Sulfur, which “sticks” to the attacking enemy substance and eliminates it from the body.
Additionally, MSM supplementation may help maintain Glutathione levels by helping decrease inflammation and Oxidative Stress, as well as by participating in the metabolism of Cysteine and Methionine, and by contributing the continuous supply of Sulfur for many vital processes in the body. Other research studies reveal of MSM’s mild protective effect on articular (bone) cartilage when facing osteoarthritis and RA, which seems to be primarily temporary pain relief. Nevertheless, published peer-reviewed clinical research in the U.S. has shown MSM is safe and effective in increasing joint comfort and supporting a normal range of motion.
*Selenium (Selenomethionine)
Selenomethionine is the most bioavailable, pure, and safe form of Selenium, a high-powered antioxidant trace mineral (which is found naturally in soil), that can effectively neutralize Free Radicals - which may lead to severe cell damage – via its ability to deplete these reactive oxygen species, thus it is considered an important precursor of Glutathione.
Small amounts of Selenium have been found necessary for several biologic processes including immune response and thyroid function. As to the latter, a recent study by the Institute of Medicine and Nutrition in Oldenburg (Germany) demonstrated Selenium to be highly beneficial for people suffering from a low thyroid function.
Small amounts of Selenium have been found necessary for several biologic processes including immune response and thyroid function. As to the latter, a recent study by the Institute of Medicine and Nutrition in Oldenburg (Germany) demonstrated Selenium to be highly beneficial for people suffering from a low thyroid function.
The above-described Twelve (12) Natural Elements constitute BioActivPro TM Select Group of ‘Glutathione (GSH)–Precursors’ Nutrients, and of ‘MEEAPS’ (Muscle, Endurance, Exercise and Athletic Performance) components.
